Journal: Molecules

Article Title: Calorimetric Monitoring of the Sub-T g Crystal Growth in Molecular Glasses: The Case of Amorphous Nifedipine

doi: 10.3390/molecules30081679

Figure Lengend Snippet: ( A ) DSC curve obtained at 0.5 °C·min −1 for the freshly prepared NIF powder with particle size 20–50 μm (red data, present research) compared with the DSC curves obtained under similar conditions for NIF powders with larger particle sizes (black data, taken from ). ( B ) DSC curves obtained for the freshly prepared 20–50 μm NIF powder at different q + ; the graph is zoomed-in on the glass transition region. Exothermic effects evolve in the upward direction in both graphs.

Article Snippet: The DSC curve obtained for the fresh NIF powder at 0.5 °C·min −1 is shown in B—the arrows indicate the temperatures at which the Raman measurements were performed.

Techniques:

Journal: Molecules

Article Title: Calorimetric Monitoring of the Sub-T g Crystal Growth in Molecular Glasses: The Case of Amorphous Nifedipine

doi: 10.3390/molecules30081679

Figure Lengend Snippet: ( A , B ) DSC curves obtained at different q + for the freshly prepared NIF powder. ( C , D ) DSC curves obtained at different q + for the NIF powders annealed for 7 h at 20 °C. Exothermic effects evolve in upward direction in all graphs.

Article Snippet: The DSC curve obtained for the fresh NIF powder at 0.5 °C·min −1 is shown in B—the arrows indicate the temperatures at which the Raman measurements were performed.

Techniques:

Journal: Molecules

Article Title: Calorimetric Monitoring of the Sub-T g Crystal Growth in Molecular Glasses: The Case of Amorphous Nifedipine

doi: 10.3390/molecules30081679

Figure Lengend Snippet: ( A ) Comparison of the DSC curves obtained non-isothermally at 0.1 and 0.2 °C·min −1 for the freshly prepared NIF powder. The measurement started either at 0 °C (black data) or 25 °C (red data). ( B ) DSC curve measured for the annealed NIF powder at 0.5 °C·min −1 (red data, top and right axes). The bottom part of the graph shows the Raman spectra collected for the fully amorphous and fully crystalline NIF samples; the inset shows the region used to best distinguish between the different NIF forms (amorphous, and α p and β p polymorphs). ( C – F ) Raman spectra collected at different temperatures indicated by arrows in B; for each temperature, several spectra (represented by different colors in the graphs) were collected at different spots on the sample surface.

Article Snippet: The DSC curve obtained for the fresh NIF powder at 0.5 °C·min −1 is shown in B—the arrows indicate the temperatures at which the Raman measurements were performed.

Techniques: Comparison

Journal: Molecules

Article Title: Calorimetric Monitoring of the Sub-T g Crystal Growth in Molecular Glasses: The Case of Amorphous Nifedipine

doi: 10.3390/molecules30081679

Figure Lengend Snippet: ( A ) Kissinger dependences calculated from the T p data shown in C (points); black and red lines correspond to the linear fits of these dependences. Vertical blue line indicates the position of T g . ( B ) DSC curves obtained for the two types of NIF samples at 0.1 °C·min −1 ; activation energies determined by the Kissinger method are attributed to the particular crystallization sub-processes.

Article Snippet: The DSC curve obtained for the fresh NIF powder at 0.5 °C·min −1 is shown in B—the arrows indicate the temperatures at which the Raman measurements were performed.

Techniques: Activation Assay, Crystallization Assay

Journal: Molecules

Article Title: Calorimetric Monitoring of the Sub-T g Crystal Growth in Molecular Glasses: The Case of Amorphous Nifedipine

doi: 10.3390/molecules30081679

Figure Lengend Snippet: DSC curves obtained for the two types of NIF samples at 0.1 °C·min −1 (points) fit by the complex crystallization models based on Equations (5) and (6) (lines).

Article Snippet: The DSC curve obtained for the fresh NIF powder at 0.5 °C·min −1 is shown in B—the arrows indicate the temperatures at which the Raman measurements were performed.

Techniques: Crystallization Assay

Journal: Molecules

Article Title: Calorimetric Monitoring of the Sub-T g Crystal Growth in Molecular Glasses: The Case of Amorphous Nifedipine

doi: 10.3390/molecules30081679

Figure Lengend Snippet: Kinetic predictions of the degree of amorphous-to-crystalline conversion for the fresh ( A ) and annealed ( B ) NIF samples during the isotherm at 20 °C. The predictions are based on the kinetic parameters obtained for the DSC measurements performed at 0.1 °C·min −1 . The insets show the data zoomed-in on the initial part of the graph.

Article Snippet: The DSC curve obtained for the fresh NIF powder at 0.5 °C·min −1 is shown in B—the arrows indicate the temperatures at which the Raman measurements were performed.

Techniques: